fnctId=thesis,fnctNo=406
Effect of Molecular Weight of Poly(Ethylene Glycol) Dicarboxylate on the Properties of Cross-Linked Hydrogel Film as an Antiadhesion Barrier
- 작성자
- 이재룡
- 저자
- PilHo Huh (공동)
- 발행사항
- 발행일
- September 2017
- 저널명
- Polymer-Plastics Technology and Engineering
- 국문초록
- 영문초록
- Poly(ethylene glycol) dicarboxylate (PEGDC)/poly(ethylene oxide) (PEO) cross-linked hydrogel films were developed as an anti-adhesion barrier using an e-beam. The effects of the molecular weight of PEGDC on hydrogel properties were investigated. The decrease in molecular weight of PEGDC increased the gel fraction, and tissue adhesion, whereas the mechanical strength did not change considerably. On the other hand, the swelling ratio decreased rapidly with decreasing molecular weight of PEGDC. The cytotoxicity of PEGDC (2000 or 3000) was low, whereas that of PEGDC (1000) was higher. In animal studies, all hydrogels showed a better anti-adhesive effect compared to the control.
- 일반텍스트
- 첨부파일